SGC Publications
Last updated: 2026-03-09
Number of Publications: 107
All
| Pubmed ID | Title | Authors | Journal | Volume:Pages | Pub Date | Site | Validated |
|---|---|---|---|---|---|---|---|
| 41797988 | Evaluation of ensilication technology for ambient DNA preservation. | Blas M, Yu C, Aghababazadeh FA, Hoelscher V, Volz M, Morales L, Jarolik K, Dong X, Dobin S, Rantasalo T, Hirvonen T, Pursiheimo JP, Laine N, Homer N, Chamoun C, Pierce W, Organick L, Fehr A, Becich M, Banal JL, Youens K, Tamminen M, Haibe-Kains B, Bedard P | NAR Mol Med | 3(1):ugag011 | 2026-3-9 | Toronto | Not yet |
| 41796804 | Structure-Based Discovery of Selective Vaccinia-Related Kinase 1 Inhibitors and Fluorogenic Active-Site Probes. | Crowley-Dolen EK, Borges RJ, Charifson PS, Payne NC, de Oliveira RG, Cunha MR, Mazitschek R, Massirer KB, Mitchison TJ | J Biol Chem | 111355 | 2026-3-9 | Unicamp, UCL | Not yet |
| 41786746 | USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion. | Collotta G, Gatti M, Ungureanu IM, van Ackeren V, Rannou E, Vivalda F, Gomez Vieito D, Fishwick KM, von Aesch C, Porro A, Ungerleider K, Heidari A, Guérois R, Harding RJ, Bischof S, Balmus G, Sartori AA | Nat Commun | 2026-3-6 | Toronto | Not yet | |
| 41784089 | Novel monoclonal antibodies against the C-terminal HEAT domain of huntingtin. | Park YN, Fanti R, Sadeghi S, Chandrasekaran R, Edwards AM, Harding RJ, Houston DW | J Huntingtons Dis | 18796397261426634 | 2026-3-5 | Toronto | Not yet |
| 41773233 | A guide to selecting high-performing antibodies for STXBP1 (UniProt ID: P61764) for use in western blot, immunoprecipitation, and immunofluorescence. | Ayoubi R, Alende C, Fotouhi M, González Bolívar S, Laflamme C | F1000Res | 13:1557 | 2024-12-24 | Neuro | Not yet |
| 41764184 | Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification. | Jansche R, Heitmeir B, Faust U, Pospiech H, Sutter C, Albig C, Hennig F, Janni W, Schmutzler R, Hauke J, Joerger AC, Wiesmüller L | Cell Death Dis | 2026-3-1 | Frankfurt | Not yet | |
| 41748563 | Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt. | Mavridi D, Funk JS, Balourdas DI, Krämer A, Khan Tareque R, Timofeev O, Spencer J, Stiewe T, Joerger AC | Cell Death Dis | 2026-2-27 | Frankfurt | Not yet | |
| 41739268 | Cupriavidus necator, an alternative source for isotopic enrichment of proteins expressed in insect cells for NMR investigations. | Gande SL, Sreeramulu S, Saxena K, Rupprecht F, Langer JD, Heumann H, Schwalbe H | J Biomol NMR | 80(1): | 2026-2-25 | Frankfurt | Not yet |
| 41738163 | Assessing Aβ-independent effects of Module 42 on immune function in vitro. | Ajith I, Bakshi S, Mead E, Gileadi O, Katis VL, Brennan PE, Gospodinova KO | Alzheimers Dement | 22(2):e71215 | 2026-2-25 | Oxford | Not yet |
| 41735282 | The N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A. | Hultman J, Morad V, Tanner E, Kenney TMG, Pietras Z, Khare LP, Derbyshire D, Resetca D, Arrowsmith CH, Aili D, Ekström S, Penn LZ, Wallner B, Ahlner A, Sunnerhagen M | Nat Commun | 17(1): | 2026-2-25 | Toronto | Not yet |
| 41719605 | Anti-MDA5 monoclonal antibodies from patients with dermatomyositis - B cell characteristics and differential targeting of the helicase domains. | Van Gompel E, Galešić M, Delaroque N, Kern K, Stålesen R, Notarnicola A, Demirdal D, Hansson M, van Vollenhoven A, Wigren E, Gräslund S, Szardenings M, Malmström V, Lundberg IE, Horuluoglu B, Grönwall C, Chemin K, Joshua V | J Autoimmun | 159:103536 | 2026-2-20 | Stockholm | Not yet |
| 41718545 | Development of a Dual Chemical Probe for the USP16 and HDAC6 Zinc-Finger Ubiquitin-Binding Domain. | Silva M, Mann M, Mirabi B, Szewczyk MM, Loup J, Dupeux A, Chandrasekaran R, Bajohr J, Arrowsmith C, Schapira M, Lautens M, Barsyte-Lovejoy D, Harding RJ, Santhakumar V | J Med Chem | 2026-2-20 | Toronto | Not yet | |
| 41716354 | A guide to selecting high-performing antibodies for Optineurin (UniProt ID: Q96CV9) for use in western blot, immunoprecipitation, and immunofluorescence. | Moleón VR, Ayoubi R, Alende C, Fothouhi M, Ryan J, Bolívar SG, Worrall D, Durcan TM, Brown CM, Francis V, McPherson PS, Laflamme C | F1000Res | 14:1137 | 2026-2-20 | Neuro | Not yet |
| 41674365 | Synthesis and Characterization of ULK1/2 Kinase Inhibitors That Inhibit Autophagy and Upregulate Expression of Major Histocompatibility Complex I for the Treatment of Non-Small Cell Lung Cancer. | Layng FIAL, Ren H, Bakas NA, Panickar DR, Lambert LJ, Celeridad M, Wu J, De Backer L, Chandrachud P, Limpert AS, Vamos M, Chaikuad A, Verdugo BB, Hagan PM, Brun SN, Tautz L, Knapp S, Shaw RJ, Salvesen GS, Sheffler DJ, Cosford NDP | ACS Chem Biol | 2026-2-12 | Frankfurt | Y | |
| 41651452 | Cellular Context Influences Kinase Inhibitor Selectivity. | Binder MJ, Bashore FM, Dunn Hoffman KK, Damgaard C, Slater M, Drewry DH, Robers MB, Axtman AD | J Med Chem | 2026-2-7 | UNC | Y | |
| 41603458 | Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening. | Isaksson R, Carter EM, Hind CK, Sutton JM, Rudgyard H, Roberts AH, Moon CW, Wang Y, Codony S, Martínez AL, Bacon J, Todd MH | J Med Chem | 2026-1-28 | UCL | Y | |
| 41587072 | Development of a Chemical Probe to Enable Characterization of the Casein Kinase 1γ Subfamily. | Capener JL, Kramer TW, Bashore FM, Flory E, Li F, Strang BL, Axtman AD | J Med Chem | 2026-1-26 | UNC | Y | |
| 41581867 | A disease-causing Isoleucyl-tRNA synthetase variant leads to altered protein complex formation and cellular stress response. | Gao H, Tennakoon R, Araújo FP, Miller JM, Nyandwi SP, Shi Q, Padilla-Martínez JP, Peng H, Cui H | J Biol Chem | 111196 | 2026-1-26 | Toronto | Y |
| 41577992 | Glioblastoma stem cells show transcriptionally correlated spatial organization. | Ayyadhury S, Sachamitr P, Kushida MM, Park NI, Coutinho FJ, Whitley O, Prinos P, Arrowsmith CH, Dirks PB, Pugh TJ, Bader GD | Commun Biol | 2026-1-24 | Toronto | Y | |
| 41575171 | Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery. | Mitrović M, Greco FA, García YC, Lučić A, Hoffmann L, Chander R, Schönfeld J, Liebisch N, Sivashanmugam SA, Schwalm MP, Egner M, Lewandowski M, Merk D, Morasch V, Wolf E, Müller S, Hanke T, Proschak E, Hiesinger K, Knapp S | J Med Chem | 2026-1-23 | Frankfurt | Y | |
| 41569870 | Structural basis for sequence-specific DNA recognition by a group IId WRKY transcription factor GhWRKY17 in cotton. | Xiao Q, Wang Y, Shang X, Chen Y, Zhang M, Zhou Y, Huang X, Qin S, Min J, Xu G, Liu Y | Biochem J | 483(2): | 2026-1-22 | Toronto | Y |
| 41568342 | S-adenosylhomocysteine analogs selectively suppress pan-coronavirus replication by inhibition of nsp14 methyltransferase. | Rosas-Lemus M, Athe S, Minasov G, Pattie JA, Brunzelle JS, Chau I, Li F, Vedadi M, Ma H, Ramanathan A, Becker ME, Hope TJ, Abdelkarim H, Grudzien P, Gaponenko V, Montgomery JE, Moellering RE, Rawal VH, Satchell KJF | ACS Med Chem Lett | 2026-1-22 | Toronto | Y | |
| 41565251 | CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2. | Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M | J Chem Inf Model | 2026-1-22 | Toronto | Y | |
| 41506723 | A Hanks-type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation. | Lima LDP, Sriranganadane D, da Silva DL, Drebes Dörr NC, Mello EBS, Dos Reis CV, Lourenço RF, Santos JFTDS, Salmazo A, Miranda BW, Massirer KB, Couñago RM, Alvarez-Martinez CE | FEBS J | 2026-1-9 | Unicamp, UNC | Y | |
| 41495240 | Discovery of predictive biomarkers for cancer therapy through computational approaches. | Wang X, Nguyen J, Nader K, Miihkinen M, Wall P, Singhal A, Bedard PL, Ideker T, Aittokallio T, Haibe-Kains B | Nat Rev Clin Oncol | 2026-1-7 | Toronto | Y | |
| 41495225 | Advances in BRET probes for intracellular target engagement studies. | Capener JL, Schwalm MP, Vasta JD, Michaud A, Teske KA, Marsiglia WM, Huber KVM, Dar AC, Knapp S, Axtman AD, Robers MB | Nat Chem Biol | 2026-1-7 | UNC, Oxford, Frankfurt | Y | |
| 41451871 | PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice. | Yang T, Huhe H, Williams SP, Kaur S, Ay YA, Davis-Gilbert ZW, Cary GA, Paisie C, Butler RR 3rd, Wiley J, Betarbet R, Fu H, Duong D, Seyfried NT, Leal K, Carter GW, Edwards A, Levey AI, Capener JL, Drewry DH, Hossain MA, Oh HJ, Axtman AD, Sukoff Rizzo SJ, Longo FM | Alzheimers Dement | 21(12):e71033 | 2025-12-26 | UNC, Toronto | Y |
| 41435866 | Basic Science and Pathogenesis. | Ayoubi R, Edwards AM, McPherson PS, Laflamme C | Alzheimers Dement | 21 Suppl 1:e100417 | 2025-12-24 | Toronto, Neuro | Y |
| 41432309 | Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities. | Taherian F, Mabanglo MF, Hajian T, Tucker S, Kalinic E, Perveen S, Aman A, Vedadi M | Protein Sci | 35(1):e70428 | 2025-12-23 | Toronto | Y |
| 41410930 | Enhancing Clinical Cancer Research Through Sharing of Data and Biospecimens. | Wildiers H, Adam V, O'Reilly S, Van Cauwenberge J, Arahmani A, Arteaga CL, Bedard PL, Bliss J, Boussis P, Brain E, Buyse M, Caballero C, Cameron D, Cardoso F, Carrasco E, Casas A, Chua B, Curigliano G, DeMichele A, Esserman L, Floris G, Goetz MP, Goulioti T, Haibe-Kains B, Hodgdon C, Ignatiadis M, Kok M, Lacombe D, Linderholm B, Loi S, Lord CJ, MacKenzie M, Maues J, Meheus L, Needham J, Neven P, Parsons H, Piccart M, Pusztai L, Razis E, Saji S, Schumacher-Wulf E, Sonke GS, Spanic T, Tannock IF, Tutt A, Urruticoechea A, van 't Veer L, Vaz-Luis I, Werutsky G, Yee D, Zaman K, Desmedt C | JAMA Oncol | 2025-12-18 | Toronto | Y | |
| 41407727 | Enantioselective protein affinity selection mass spectrometry (E-ASMS). | Wang X, Sun J, Ahmad S, Yang D, Li F, Chan UH, Zeng H, Simoben CV, Green SR, Silva M, Houliston S, Dong A, Bolotokova A, Gibson E, Kutera M, Ghiabi P, Kondratov I, Matviyuk T, Chuprina A, Mavridi D, Lenz C, Joerger AC, Brown BD, Heath RB, Yue WW, Robbie LK, Beyett TS, Müller S, Knapp S, Owen DR, Harding R, Schapira M, Brown PJ, Santhakumar V, Ackloo S, Arrowsmith CH, Edwards AM, Peng H, Halabelian L | Nat Commun | 2025-12-18 | Toronto, Oxford, Frankfurt | Y | |
| 41358868 | Overcoming Ligand Discovery Challenges: Developing Peptide-Based Tracers for SPSB2. | Lenz C, Elson L, Dopfer J, Farges F, Krämer A, Löhr F, Müller S, Guéret SM, Waldmann H, Dötsch V, Saxena K, Knapp S | ACS Chem Biol | 2025-12-8 | Frankfurt | Y | |
| 41345223 | Targeting bacterial kinases as a strategy to counteract antibiotic resistance. | Buffa V, Kowalewski J, Qi G, Deutscher R, Cica M, Richardoz M, Tomaszczyk M, Krämer A, Knapp S, Dunyach-Remy C, Rox K, Guichou JF, Lionne C, Hausch F | Commun Chem | 8(1):390 | 2025-12-5 | Frankfurt | Y |
| 41341144 | A guide to selecting high-performing antibodies for Heterogeneous nuclear ribonucleoproteins A2/B1(hnRNP A2/B1) (UniProt ID: P22626) for use in western blot, immunoprecipitation, and immunofluorescence. | Moleón VR, Ayoubi R, Alende C, Fothouhi M, Ryan J, Bolívar SG, Worrall D, Durcan TM, Brown CM, Francis V, McPherson PS, Laflamme C | F1000Res | 14:1158 | 2025-12-4 | Neuro | Y |
| 41317486 | Target engagement in bacterial and protozoan pathogens: in vitro and cellular assays for drug discovery. | Ramos PZ, Catta-Preta CMC, Couñago RM | Curr Opin Struct Biol | 96:103194 | 2025-11-30 | UNC | Not yet |
| 41292551 | Identification of spirodioxolane nsP2 helicase inhibitors with antialphaviral activity. | Oh HJ, Sears JD, Ramalingam BM, Saleem RSZ, Davis-Gilbert ZW, Hossain MA, Moorman SR, Ohja D, Martinez SA, Burdick JE, Couñago RM, Moorman NJ, Heise MT, Todd MH, Willson TM | RSC Med Chem | 2025-11-26 | UNC, UCL | Y | |
| 41267475 | Water Networks as Hydrophobic Recognition Motifs in Proteins. | Piticchio SG, Martínez-Cartró M, Scaffidi S, Rodríguez-Arévalo S, Bagán A, Sánchez-Arfelis A, Picaud S, Krojer T, Filippakopoulos P, von Delft F, Escolano C, Galdeano C, Barril X | Angew Chem Int Ed Engl | e21138 | 2025-11-21 | Oxford | Y |
| 41260215 | Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability. | Kröll-Hermi A, Stoetzel C, Etard C, Halabelian L, Schaefer E, Scheidecker S, Kahrizi K, Payman J, Geoffroy V, Prasad M, Obringer C, Ruch L, Girard A, Zeng H, Li F, Plassard D, Keime C, Mattioli F, Feger C, Piton A, Fujita A, Matsumoto N, Castro MAA, Ae KC, Ruaud L, Levy J, Dozières B, Tabet AC, Wentzensen IM, Santiago-Sim T, Yusupov R, Tveten K, Smeland MF, Alkhunaizi E, Cowing G, Li C, Wortmann SB, Feichtinger RG, Mayr JA, Gonorazky H, Jing G, Wang X, Wang J, Bierhals T, Grinstein L, Herget T, Ruiz A, Gabau E, Kampmeier A, Kassel O, Kuechler A, Platzer K, Jamra RA, Woerner A, Idleburg M, Kircher SG, Laccone F, Golob B, Peterlin B, Čuturilo G, Tasic V, Kolvenbach CM, Hildebrandt F, Ramos LLP, Kok F, Buck CB, van de Laar IMBH, de Man SA, Taşdelen E, Sezer A, Büke A, Yavuz Z, Çomoğlu SS, Costin C, Tran Mau Them F, Lacaze E, Courtin T, Héron D, Keren B, Whalen S, Roume J, Yang Y, Hoffer MJV, van Haeringen A, Najmabadi H, Arrowsmith CH, Strähle U, Dollfus H, Muller J | Am J Hum Genet | 2025-11-20 | Toronto | Y | |
| 41258112 | BRSK2 plays a role in autophagy and cancer cell growth and survival under nutrient deprivation stress via the PIK3C3 pathway. | Maiti A, Axtman AD, Wu R, Redman LJB, Takabe K, Stablewski AB, Yan L, Ciesielski MJ, Zhang J, Evans SS, Kalinski P, Hait NC | Sci Rep | 15(1):40651 | 2025-11-19 | UNC | Y |
| 41256983 | Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK). | Dettenhöfer M, Tandara LN, Amrhein JA, Kurz CG, Schwalm MP, Mensing TE, Wahl LM, Krämer A, Gerninghaus J, Lenz C, Elson L, Berger BT, Schröder M, Saxena K, Müller S, Knapp S, Greco FA, Hanke T | ACS Med Chem Lett | 16(11):2086-2096 | 2025-11-19 | Frankfurt | Y |
| 41195166 | Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1. | Hank EC, D'Arcy-Evans ND, Scaletti ER, Benítez-Buelga C, Wallner O, Ortis F, Zhou K, Meng L, Del Prado A, Calvo P, Almlöf I, Wiita E, Nierlin K, Košenina S, Krämer A, Eddershaw A, Kehler M, Long M, Jemth AS, Dawson H, Stewart J, Dickey A, Astorga ME, Varga M, Homan EJ, Scobie M, Knapp S, Sastre L, Stenmark P, de Vega M, Helleday T, Michel M | RSC Chem Biol | 2025-11-6 | Frankfurt | Y | |
| 41182902 | Nucleosome context regulates chromatin reader preference. | Marunde MR, Popova IK, Hall NW, Vaidya A, Bone JR, Boone BA, Brown PJ, Ezell RJ, Firestone TM, Fuchs HA, Gibson E, Gillespie ZB, Gloor SL, Hickman AR, Howard SA, Husby NL, Hsiung VT, Johnstone AL, Khan LF, Krajewski K, Lee AS, McAnarney ET, Maier KE, Maryanski DN, McCuiston JL, Noll KE, Novitzky K, Patteson EF, Rodriguez KL, Sanchez JC, Schachner LF, Smith CE, Sun L, Taylor HF, Watson R, Willis HE, Musselman CA, Venters BJ, Cheek MA, Meiners MJ, Sun ZW, Kelleher NL, Cowles MW, Weinzapfel EN, Keogh MC, Burg JM | Nucleic Acids Res | 53(20): | 2025-11-3 | Toronto | Y |
| 41166698 | Multiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery. | Ianevski A, Nader K, Nguyen J, Sorger H, Timonen S, Julia E, Pölöske D, Spirk K, Wagner C, Jungherz D, Nakano M, Kadambat Nair S, Ianevski P, Kankainen M, Dias D, Cichońska A, Pemovska T, Pirker C, Berger W, Braun T, Moriggl R, Bachy E, Mustjoki S, Herling M, Neubauer HA, Haibe-Kains B, Aittokallio T | Cancer Res | 86(2):295-309 | 2025-10-30 | Toronto | Not yet |
| 41154634 | NEK Family Kinases: Structure, Function, and Role in Disease. | Baker BM, Boehling JR, Knopf S, Held S, Matossian M, Belgodere JA, Hoang VT, Collins-Burow BM, Martin EC, Lee SB, Burow ME, Drewry DH, Newman RH | Biomolecules | 15(10): | 2025-10-29 | UNC | Y |
| 41135522 | Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression. | Zhang M, Chen M, Li P, Min J | Cell Chem Biol | 2025-10-25 | Toronto | Y | |
| 41125721 | GraphComm predicts cell cell communication using a graph based deep learning method in single cell RNA sequencing data. | So E, Hayat S, Nair SK, Wang B, Haibe-Kains B | Sci Rep | 15(1):36914 | 2025-10-23 | Toronto | Y |
| 41120092 | Click chemistry enables rapid development of potent sEH PROTACs using a direct-to-biology approach. | Schönfeld J, Liebisch N, Brunst S, Weizel L, Knapp S, Kannt A, Proschak E, Hiesinger K | Chem Commun (Camb) | 2025-10-22 | Frankfurt | Y | |
| 41113115 | Structure-activity relationships of fenarimol analogues with potent in vitro and in vivo activity against Madurella mycetomatis, the main causative agent of mycetoma. | Duong HP, Melechov D, Lim W, Ma J, Scroggie KR, Rajendra L, Perry B, Cruz LR, Saleem RSZ, Rutledge PJ, Motion A, van de Sande WWJ, Todd MH | RSC Med Chem | 2025-10-20 | UCL | Y | |
| 41102521 | Cysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death. | Gotthardt G, Weckesser J, Tascher G, Barros da Gama S, Uckelmann HJ, Sun S, Schwalm MP, Mosler T, Ferrario G, Friedmann Angeli JP, Münch C, Knapp S, Müller S | EMBO Rep | 2025-10-17 | Frankfurt | Y | |
| 41090377 | N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad-Spectrum Antialphaviral Activity. | Ghoshal A, Sears JD, Hossain MA, Tse EG, Howell S, Burdick JE, Morales NL, Martinez SA, Law I, Streblow ZJ, Streblow DN, Couñago RM, Moorman NJ, Heise MT, Willson TM | J Med Chem | 2025-10-15 | UNC | Y | |
| 41047897 | Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders. | Wellnitz J, Ahmad S, Bagale N, Cheng X, Joseph J, Zeng H, Bolotokova A, Dong A, Reza S, Ghiabi P, Gibson E, Tu G, Li X, Liu J, Dou D, Li J, Foley TL, Harris AR, Klug-McLeod JL, Lee J, Lengyel-Zhand Z, Montgomery JI, Sakata S, Zhang J, Zhu H, Owen DR, Harding RJ, Edwards AM, Haibe-Kains B, Halabelian L, Tropsha A, Couñago RM | J Med Chem | 2025-10-6 | UNC, Toronto | Y | |
| 41043390 | A needed nomenclature for nucleosomes. | Keogh MC, Almouzni G, Andrews AJ, Armache KJ, Arrowsmith CH, Baek SH, Bedford MT, Bernstein E, Côté J, David Y, Denu JM, Fierz B, Garcia BA, Glass KC, Gozani O, Helin K, Henikoff S, Jensen ON, Josefowicz SZ, Kelleher NL, Kutateladze TG, Lindner HH, Lu C, Luger K, Mallick P, Musselman CA, Muir TW, Paša-Tolić L, Schneider R, Shi X, Shi Y, Sidoli S, Smith LM, Tyler JK, Wolberger C, Workman JL, Strahl BD, Young NL | Mol Cell | 85(19):3554-3561 | 2025-10-4 | Toronto | Y |
| 40994280 | Discovery and Characterization of Cell-Permeable Inhibitors of Leishmania mexicana CLK1 Using an In-Cell Target Engagement Assay. | Catta-Preta CMC, Ramos PZ, Carnielli JBT, Vasconcelos SNS, Dowle A, Fanti RC, Dos Reis CV, Coelho AC, Massirer KB, Mottram JC, Couñago RM | ACS Infect Dis | 2025-9-25 | Unicamp, UNC | Y | |
| 40973081 | Large Library Docking and Biophysical Analysis of Small-Molecule TMPRSS2 Inhibitors. | Fraser BJ, Young NJ, Bender BJ, Gahbauer S, Ilyassov O, Wilson RP, Li Y, Seitova A, Lourenço AL, Chung DH, Bardine C, Bénard F, Shoichet BK, Craik CS, Arrowsmith CH | J Med Chem | 2025-9-20 | Toronto | Y | |
| 40952355 | Site-Specific Hydrogen Deuterium Exchange Difference Mass Spectrometry Measurements for Ligand Binding. | Anacleto J, Ackloo S, Arrowsmith C, Wolf E, Leblanc Y, Lento C, Wilson DJ | J Am Soc Mass Spectrom | 2025-9-15 | Toronto | Y | |
| 40927425 | Discovery of an exquisitely selective WDR5 chemical probe accelerated by a high-quality DEL-ML Hit. | Hoffmann L, Lenz C, Farges F, Kimani SW, Dopfer J, Keller S, Schwalm MP, Holzmann H, Kraemer A, Dong A, Li F, Chau I, Halabelian L, Gstaiger M, Müller S, Knapp S, Němec V | RSC Chem Biol | 2025-9-10 | Toronto, Frankfurt | Y | |
| 40904251 | A soft-stiff patterned bioengineering model reveals kinase pathways driving directional cell migration in pulmonary arterial hypertension. | Islam T, Hooper J, Zhang X, Garcia C, Hasan MM, Drewry DH, Hossain MA, Al-Hilal TA | Biomater Sci | 2025-9-4 | UNC | Y | |
| 40883309 | Characterization of PROTAC specificity and endogenous protein interactomes using ProtacID. | Shrestha S, Maitland MER, Jing L, Duan S, Nie DY, St-Germain J, Kanaris M, Barsyte-Lovejoy D, Arrowsmith CH, Raught B | Nat Commun | 16(1):8089 | 2025-8-31 | Toronto | Y |
| 40882436 | Development of pyrazolo[1,5-a]pyrimidine based macrocyclic kinase inhibitors targeting AAK1. | Mensing TE, Kurz CG, Amrhein JA, Ehret TAL, Preuss F, Mathea S, Karim M, Tran DHN, Kadlecova Z, Tolvanen TA, Martinez-Molina D, Müller S, Einav S, Knapp S, Hanke T | Eur J Med Chem | 299:118076 | 2025-8-30 | Frankfurt | Y |
| 40839780 | k-Nearest Neighbor Adaptive Sampling, a Simple Tool to Efficiently Explore Conformational Space. | Rovers E, Thudi A, Hénin J, Maddison CJ, Schapira M | J Chem Theory Comput | 2025-8-21 | Toronto | Y | |
| 40833013 | Chemical proteomics reveals human liver fatty acid binding protein as a predominant and selective target of triphenyl phosphate. | Miller J, Han J, Yang D, Diamond ML, Liu R, Peng H | Environ Sci Process Impacts | 2025-8-20 | Toronto | Y | |
| 40821731 | Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design. | Zhubi R, Chaikuad A, Muñoz Sosa CJ, Joerger AC, Knapp S | J Struct Biol X | 12:100134 | 2025-8-18 | Frankfurt | Y |
| 40774384 | NUAK kinases: signaling mechanisms and therapeutic applications. | Cullen NM, Rosston P, Tufail B, D'Armond AE, Patel A, Khosravi DH, Burow BC, Hoang VT, Martin EC, Drewry DH, Burow ME, Alahari SK | J Biol Chem | 110565 | 2025-8-8 | UNC | Y |
| 40756524 | A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2. | Hillebrand L, Wang G, Rasch A, Masberg B, Chaikuad A, Kronenberger T, Günther E, Forster M, Poso A, Lämmerhofer M, Laufer SA, Knapp S, Gehringer M | RSC Med Chem | 2025-8-4 | Frankfurt | Y | |
| 40702244 | Protein-ligand data at scale to support machine learning. | Aled M. Edwards, Dafydd R. Owen, Leili Zhang, Damian W. Young, Timothy M. Willson, James Wellnitz, Yanli Wang, Jarrod Walsh, Erik Vernet, Alexander Tropsha, Claudia Tredup, Matthew H. Todd, Amelia Tjaden, Sven Thamm, Michael Sundström, Andreas Steffen, Shaun Stauffer, Lucas Rodrigo de Souza, Min Shen, Kristof Schütt, Lovisa Holmberg Schiavone, Matthieu Schapira, Santha Santhakumar, Kumar Saikatendu, Emma Rivers, Dušan Petrović, Hui Peng, John P. O’Donnell, Susanne Müller-Knapp, Anke Mueller-Fahrnow, Maxwell R. Morgan, Florian Montel, Juan Carlos Mobarec, Maurice Michel, Sofia Melliou, Uta Lessel, Andrew R. Leach, Oliver Krämer, Florian Krieger, Stefan Knapp, Anthony Keefe, Aimo Kannt, Scott A. Johnson, Sandra Häberle, Emily Rose Holzinger, Ingo V. Hartung, Rachel J. Harding, Thomas Hanke, Levon Halabelian, Benjamin Haibe-Kains, Judith Günther, Marie-Aude Guié, Claudia Gordijo, Opher Gileadi, Luca Foschini, Amaury Fernández-Montalván, Ola Engkvist, Madison M. Edwards, Katharina Duerr, David Drewry, Dengfeng Dou, Snezana Djordjevic, Alejandra Solache Diaz, Sergio Martinez Cuesta, Rafael Counago, Wendy D. Cornell, Jesse A. Coker, Djork-Arné Clevert, Timothy Cernak, Nicola A. Burgess-Brown, Peter J. Brown, Mario H. Bengtson, Frances M. Bashore, Dalia Barsyte-Lovejoy, Arrash J. Baghaie, Alison D. Axtman, Cheryl Arrowsmith, Albert A. Antolin & Suzanne Ackloo | Nat Rev Chem | 2025-7-24 | Unicamp, UNC, UCL, Toronto, Stockholm, Frankfurt | Y | |
| 40683980 | OICR-41103 as a chemical probe for the DCAF1 WD40 domain. | Kimani SW, Noureldin M, Wilson B, Hoffer L, Green SR, Szewczyk MM, González-Álvarez H, Mohammed M, Chan M, Krausser C, Li ASM, Hajian T, Tucker S, Joshi D, Saraon P, Thériault B, Kim JS, Santhakumar V, Loppnau P, Li Y, Seitova A, Dong A, Kiyota T, Hammann T, Gehrtz P, Patel B, Rathod V, Vala A, Rout B, Jagodra P, Brown PJ, Aman A, Ramnauth J, Poda G, Uehling D, Arrowsmith CH, Barsyte-Lovejoy D, Marcellus R, Ackloo S, Mamai A, Al-Awar R, Halabelian L | Commun Biol | 8(1):1076 | 2025-7-20 | Toronto | Y |
| 40680191 | Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity. | Muthu Ramalingam B, Oh HJ, Sears JD, Chen CH, Vala A, Liu S, Talbot KM, Hossain MA, Brown PJ, Houliston S, Garcia Perez J, Li F, Amare MG, Halfmann P, Smith JL, Hirsch AJ, Arrowsmith CH, Halabelian L, Vargason A, Couñago RM, Arnold JJ, Cameron CE, Moorman NJ, Heise MT, Willson TM | ACS Infect Dis | 2025-7-18 | UNC, Toronto | Y | |
| 40666473 | Exploring the Ligandability of 53BP1 through Fragment-Based Approaches. | Chiew B, Gunzburg MJ, Foley CA, Zeng H, Dong A, Brown PJ, The J, Norris-Drouin JL, Cholensky SH, Mohanty B, Scanlon MJ, Headey SJ, Doak BC, James LI | ACS Med Chem Lett | 16(7):1290-1298 | 2025-7-16 | Toronto | Y |
| 40664145 | The use of machine learning models to predict progression-free survival and overall survival outcomes from waterfall plots in randomized clinical trials (MAP-OUTCOMES). | Alshankati K, Alshibany A, Toma A, Lajkosz K, Haibe-Kains B, Siu LL | ESMO Open | 10(8):105509 | 2025-7-16 | Toronto | Y |
| 40657179 | A guide to selecting high-performing antibodies for Stearoyl-CoA desaturase (SCD1) (UniProt ID: O00767) for use in western blot, immunoprecipitation, and immunofluorescence. | Ruíz Moleón V, Alende C, Fotouhi M, González Bolívar S, Ayoubi R, Laflamme C | F1000Res | 14:10 | 2025-7-14 | Neuro | Y |
| 40634283 | Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity. | Muthu Ramalingam B, Sears JD, Talbot KM, Su YN, Houliston S, Hossain MA, Davis-Gilbert ZW, Zhao C, Oh HJ, Brown PJ, Sanders MK, Moorman SR, Ojha D, Burdick JE, Law I, Morales NL, Martinez SA, Loppnau P, Garcia Perez J, Drobish AM, Morrison TE, Streblow ZJ, Streblow DN, Arrowsmith CH, Vargason A, Couñago RM, Halabelian L, Arnold JJ, Cameron CE, Moorman NJ, Heise MT, Willson TM | J Med Chem | 2025-7-10 | UNC, Toronto | Y | |
| 40624741 | Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase. | Fiesel F, Bustillos B, Watzlawik J, Chen C, Berryer M, Zhang J, Boneski P, Hayes C, Bredenberg J, Deneault E, You Z, Abdien N, Aprahamian N, Goldsmith T, Baninameh Z, Cocker L, Zhang H, Goldberg M, Fon E, Trempe JF, Virdee S, Durcan T, Springer W | Autophagy | 2025-7-8 | Neuro | Y | |
| 40598933 | Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor. | Mandel S, Hanke T, Prendiville N, Baena-Nuevo M, Berger LM, Farges F, Schwalm MP, Berger BT, Kraemer A, Elson L, Saraswati H, Abdul Azeez KR, Dederer V, Mathea S, Corrionero A, Alfonso P, Keller S, Gstaiger M, Krause DS, Müller S, Röhm S, Knapp S | J Med Chem | 2025-7-2 | Frankfurt | Y | |
| 40539604 | CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13. | Herasymenko O, Silva M, Abu-Saleh AAA, Ahmad A, Alvarado-Huayhuaz J, Arce OEA, Armstrong RJ, Arrowsmith C, Bachta KE, Beck H, Berta D, Bieniek MK, Blay V, Bolotokova A, Bourne PE, Breznik M, Brown PJ, Campbell ADG, Carosati E, Chau I, Cole DJ, Cree B, Dehaen W, Denzinger K, Dos Santos Machado K, Dunn I, Durai P, Edfeldt K, Edwards A, Fayne D, Felfoldi D, Friston K, Ghiabi P, Gibson E, Günther J, Gunnarsson A, Hillisch A, Houston DR, Jensen JH, Harding RJ, Harris KS, Hoffer L, Hogner A, Horton JT, Houliston S, Hultquist JF, Hutchinson A, Irwin JJ, Jukič M, Kandwal S, Karlova A, Katis VL, Kich RP, Kireev D, Koes D, Inniss NL, Lessel U, Liu S, Loppnau P, Lu W, Martino S, McGibbon M, Meiler J, Mettu A, Money-Kyrle S, Moretti R, Moroz YS, Muvva C, Newman JA, Obendorf L, Paige B, Pandit A, Park K, Perveen S, Pirie R, Poda G, Protopopov M, Pütter V, Ricci F, Roper NJ, Rosta E, Rzhetskaya M, Sabnis Y, Satchell KJF, Schmitt Kremer F, Scott T, Seitova A, Steinmann C, Talagayev V, Tarkhanova OO, Tatum NJ, Treleaven D, Velasque Werhli A, Walters WP, Wang X, Wells J, Wells G, Westermaier Y, Wolber G, Wortmann L, Zhang J, Zhao Z, Zheng S, Schapira M | J Chem Inf Model | 2025-6-20 | Toronto | Y | |
| 40535172 | A guide to selecting high-performing antibodies for Rab10 (UniProt ID: P61026) for use in western blot, immunoprecipitation, and immunofluorescence. | Ruíz Moleón V, Alende C, Fotouhi M, Southern K, Ayoubi R, Laflamme C | F1000Res | 13:1061 | 2025-6-19 | Neuro | Y |
| 40535171 | A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence. | Ruíz Moleón V, Alende C, Fotouhi M, Ayoubi R, Southern K, Laflamme C | F1000Res | 13:1049 | 2025-6-19 | Neuro | Y |
| 40532036 | Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase. | Schönfeld J, Brunst S, Ciomirtan L, Willmer L, Chromik MA, Kumar A, Froemel T, Liebisch N, Hackspacher A, Ehrler JHM, Wintermeier L, Hesse C, Fiedler J, Heering J, Freitag H, Zardo P, Fieguth HG, Brüggerhoff A, Jakob J, Häupl B, Weizel L, Kaiser A, Schubert-Zsilavecz M, Oellerich T, Fleming I, Schebb NH, Fürst R, Kannt A, Knapp S, Proschak E, Hiesinger K | J Med Chem | 2025-6-18 | Frankfurt | Y | |
| 40514378 | Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain. | Kim Y, Lučić A, Lenz C, Farges F, Schwalm MP, Saxena K, Hanke T, Marples PG, Aschenbrenner JC, Fearon D, von Delft F, Krämer A, Knapp S | Commun Chem | 8(1):185 | 2025-6-14 | Oxford, Frankfurt | Y |
| 40494107 | Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling. | Fan X, Li X, Li T, Shao B, Niu S, Fan W, Wang Q, Zhong L, Wang X, Wang Z, Ma F, Zheng G, Peng H, Chen L, Dong Z | Environ Int | 201:109591 | 2025-6-11 | Toronto | Y |
| 40465731 | Type II kinase inhibitors that target Parkinson's disease-associated LRRK2. | Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Krämer A, Schwalm MP, Lattal NM, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S | Sci Adv | 11(23):eadt2050 | 2025-6-4 | Frankfurt | Y |
| 40455101 | Semiquantitative Nontargeted Screening of Organophosphorus Plastic Additives in Consumer Products Using (31)P NMR. | Chen W, Miller JM, Burns DC, Almuhtaram H, Andrews RC, Peng H | Environ Sci Technol | 59(23):11842-11852 | 2025-6-2 | Toronto | Y |
| 40415386 | Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities. | Gusev F, Gutkin E, Gentile F, Ban F, Koby SB, Li F, Chau I, Ackloo S, Arrowsmith CH, Bolotokova A, Ghiabi P, Gibson E, Halabelian L, Houliston S, Harding RJ, Hutchinson A, Loppnau P, Perveen S, Seitova A, Zeng H, Schapira M, Cherkasov A, Isayev O, Kurnikova MG | J Chem Inf Model | 2025-5-26 | Toronto | Y | |
| 40413955 | PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents. | Aparnathi MK, Ul Haq S, St-Germain J, Nixon KCJ, Walton J, Song L, Majeed S, Patel PS, Subramaniam R, Philip V, Marcellus R, Barsyte-Lovejoy D, Al-Awar R, Hakem R, Arrowsmith CH, Ailles L, Raught B, Lok BH | Neoplasia | 66:101176 | 2025-5-26 | Toronto | Y |
| 40351160 | Species-Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with In Vivo Antialphaviral Activity. | Hossain MA, Mayo AK, Ghoshal A, Taft-Benz S, Anderson E, Morales NL, Pressey KD, Vargason A, Brouwer KLR, Moorman NJ, Heise MT, Willson TM | J Med Chem | 2025-5-12 | UNC | Y | |
| 40348740 | Structural basis of TMPRSS11D specificity and autocleavage activation. | Fraser BJ, Wilson RP, Ferková S, Ilyassov O, Lac J, Dong A, Li YY, Seitova A, Li Y, Hejazi Z, Kenney TMG, Penn LZ, Edwards A, Leduc R, Boudreault PL, Morin GB, Bénard F, Arrowsmith CH | Nat Commun | 16(1):4351 | 2025-5-11 | Toronto | Y |
| 40344429 | Biochemical investigation of LC3/GABARAP-ligand interaction as an important quality measure for LC3/GABARAP-targeting small molecules: addendum to the guidelines (4th edition). | Schwalm MP, Lenz C, Saxena K, Klionsky DJ, Proschak E, Knapp S | Autophagy | 1-5 | 2025-5-9 | Frankfurt | Y |
| 40336336 | Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries. | Dreizler JK, Meyners C, Sugiarto WO, Repity ML, Maciel EVS, Purder PL, Lermyte F, Knapp S, Hausch F | J Med Chem | 68(9):9525-9536 | 2025-5-8 | Frankfurt | Y |
| 40331427 | Native Taylor/Non-Taylor Dispersion-Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening. | Eisert J, Maciel EVS, Dederer V, Berwanger A, Bailey HJ, Đikić I, Knapp S, Empting M, Mathea S, Jensen H, Lermyte F | Small Methods | e2500658 | 2025-5-7 | Frankfurt | Y |
| 40324204 | Native Flow-Induced Dispersion Analysis - Mass Spectrometry Enables Automated, Multiplexed Ligand Screening from Conventional, Nonvolatile Buffers. | Maciel EVS, Eisert J, Dederer V, Berwanger A, Knapp S, Empting M, Mathea S, Jensen H, Lermyte F | Anal Chem | 2025-5-5 | Frankfurt | Y | |
| 40316178 | Chemical arsenal for helicase Hunters: Striking the toughest targets in antiviral research. | Martin HJ, Hossain MA, Wellnitz J, Kelestemur E, Hochuli JE, Perveen S, Arrowsmith C, Willson TM, Muratov EN, Tropsha A | Antiviral Res | 239:106184 | 2025-5-3 | UNC, Toronto | Y |
| 40304179 | PRMT5 promotes full-length HTT expression by repressing multiple proximal intronic polyadenylation sites. | Yadav M, AlQazzaz MA, Ciamponi FE, Ho JC, Maron MI, Sababi AM, MacLeod G, Ahmadi M, Bullivant G, Tano V, Langley SR, Sánchez-Osuna M, Sachamitr P, Kushida M, Bardile CF, Pouladi MA, Kurtz R, Richards L, Pugh T, Tyers M, Angers S, Dirks PB, Bader GD, Truant R, Massirer KB, Barsyte-Lovejoy D, Shechter D, Harding RJ, Arrowsmith CH, Prinos P | Nucleic Acids Res | 53(8): | 2025-4-30 | Unicamp, Toronto | Y |
| 40291769 | A guide to selecting high-performing antibodies for S1PR1 (UniProt ID: P21453) for use in western blot, immunoprecipitation, and immunofluorescence. | Ayoubi R, Fotouhi M, Alende C, González Bolívar S, Southern K, Laflamme C | F1000Res | 13:792 | 2025-4-28 | Neuro | Y |
| 40259428 | Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification. | Harding RJ, Xie Y, Caron NS, Findlay-Black H, Lyu C, Potluri N, Chandrasekaran R, Hayden MR, Leavitt BR, Langbehn DR, Southwell AL | Biomark Res | 13(1):63 | 2025-4-22 | Toronto | Y |
| 40244695 | Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse. | Edmonds AK, Balourdas DI, Marsh GP, Felix R, Brasher B, Cooper J, Graber-Feesl C, Kollareddy M, Malik K, Stewart H, Chevassut TJT, Lineham E, Morley S, Fedorov O, Bennett J, Rajasekaran MB, Ojeda S, Harrison DA, Ott CJ, Joerger AC, Maple HJ, Spencer J | J Med Chem | 2025-4-17 | Oxford, Frankfurt | Y | |
| 40227881 | Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor. | Mandel S, Hanke T, Mathea S, Chatterjee D, Saraswati H, Berger BT, Schwalm MP, Yamamoto S, Tawada M, Takagi T, Ahmed M, Röhm S, Corrionero A, Alfonso P, Baena M, Elson L, Menge A, Krämer A, Pereira R, Müller S, Krause DS, Knapp S | ACS Chem Biol | 2025-4-14 | Frankfurt | Y | |
| 40197020 | Structure and Toxicity Characterization of Alkyl Hydroxylated Metabolites of 6PPD-Q. | Nair P, Barrett H, Tanoto K, Xie L, Sun J, Yang D, Yao H, Song D, Peng H | Environ Sci Technol | 59(15):7474-7484 | 2025-4-8 | Toronto | Y |
| 40194700 | ATPase activity profiling of three human DExD/H-box RNA helicases. | Li F, Chan UH, Perez JG, Zeng H, Chau I, Li Y, Seitova A, Halabelian L | SLAS Discov | 32:100229 | 2025-4-8 | Toronto | Y |
| 40182019 | A guide to selecting high-performing antibodies for TAF15 (UniProt ID: Q92804) for use in western blot, immunoprecipitation, and immunofluorescence. | Ruíz Moleón V, Alende C, Fotouhi M, Ayoubi R, Laflamme C | F1000Res | 14:37 | 2025-4-4 | Neuro | Y |
| 40163818 | From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants. | Lemieux G, Pérez-Vargas J, Désilets A, Hassanzadeh M, Thompson CAH, Gravel-Trudeau A, Joushomme A, Ennis S, Villanueva I, Marouseau É, Fraser BJ, Champagne W, Lepage M, Niikura M, Arrowsmith CH, Jean F, Leduc R, Boudreault PL | J Med Chem | 2025-3-31 | Toronto | Y | |
| 40110855 | Chemoproteomic Profiling of C. albicans for Characterization of Antifungal Kinase Inhibitors. | Shirley DJ, Nandakumar M, Cabrera A, Yiu B, Puumala E, Liu Z, Robbins N, Whitesell L, Smith JL, Lyons S, Mordant AL, Herring LE, Graves LM, Couñago RM, Drewry DH, Cowen LE, Willson TM | J Med Chem | 2025-3-20 | UNC | Y | |
| 40084939 | CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment. | Chung DC, Shakfa N, Vakharia J, Warner K, Jacquelot N, Sayad A, Han S, Ghaedi M, Garcia-Batres CR, Sotty J, Azarmina A, Nowlan F, Chen ELY, Zon M, Elford AR, Wang BX, Nguyen LT, Mrkonjic M, Clarke BA, Bernardini MQ, Haibe-Kains B, Ferguson SE, Crome SQ, Jackson HW, Ohashi PS | Cancer Immunol Res | 13(4):527-546 | 2025-3-14 | Toronto | Y |
| 39763991 | MorphoDiff: Cellular Morphology Painting with Diffusion Models. | Navidi Z, Ma J, Miglietta EA, Liu L, Carpenter AE, Cimini BA, Haibe-Kains B, Wang B | bioRxiv | 2025-1-7 | Toronto | Y | |
| 39468773 | Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens. | Andrade Meirelles M, Almeida VM, Sullivan JR, de Toledo I, Dos Reis CV, Cunha MR, Zigweid R, Shim A, Sankaran B, Woodward EL, Seibold S, Liu L, Mian MR, Battaile KP, Riley J, Duncan C, Simeons FRC, Ferguson L, Joji H, Read KD, Lovell S, Staker BL, Behr MA, Pilli RA, Couñago RM | J Med Chem | 67(21):19143-19164 | 2024-10-29 | UNC | Not yet |
| 34382010 | Structure of the Mycobacterium tuberculosis cPknF and conformational changes induced in forkhead-associated regulatory domains. | Cabarca S, Frazão de Souza M, Albert de Oliveira A, Vignoli Muniz GS, Lamy MT, Vinicius Dos Reis C, Takarada J, Effer B, Souza LS, Iriarte de la Torre L, Couñago R, Pinto Oliveira CL, Balan A | Curr Res Struct Biol | 3:165-178 | 2021-8-13 | UNC | Not yet |
| 34046602 | Identification of P218 as a potent inhibitor of Mycobacterium ulcerans DHFR. | Riboldi GP, Zigweid R, Myler PJ, Mayclin SJ, Couñago RM, Staker BL | RSC Med Chem | 12(1):103-109 | 2021-5-29 | UNC | Not yet |
| 33773911 | Raising the Bar(-seq) in Leishmania Genetic Screens. | Ferreira TR, Couñago RM, Moretti NS | Trends Parasitol | 37(5):367-369 | 2021-3-29 | UNC | Not yet |
| 33147789 | Chemical Space Exploration of Oxetanes. | Alves FRS, Couñago RM, Laufer S | Int J Mol Sci | 21(21): | 2020-11-6 | UNC | Not yet |